- Role: Honorary Research Associate
Dr Joohyung Lee was awarded his PhD in 2002, from The University of Melbourne and The Florey Institute of Neuroscience and Mental Health, in the area of neuroscience and pharmacology. He then worked as a Parkinson’s Society Canada Research Fellow at the Toronto Western Hospital in Canada, to investigate the role of abnormal synaptic plasticity in Parkinson’s Disease. In 2006, Dr Lee returned to The Florey Institute to investigate the compensatory mechanisms in the brain in Parkinson’s disease and drug addiction, before joining Prince Henry’s Institute, now Hudson Institute of Medical Research as an Honorary Research Associate.
Dr Lee’s research focuses on sex differences in brain function in normal and diseased states. In particular, the research laboratory is focusing on the potential role of the male sex-determining gene SRY in the sex differences in neurological diseases, such as Parkinson’s disease, attention-deficit hyperactive disorder (ADHD) and autism. He has a strong interest in understanding the role of the Y-chromosome gene SRY and the male brain and how abnormal regulation of SRY may increase the susceptibility of males to certain neurological disorders, such as Parkinson’s disease and schizophrenia.
Dr Lee’s expertise lies in pre-clinical models of Parkinson’s Disease and movement disorders; behavioural neuroscience, stereotaxic surgery, neurochemistry, in vivo and in vitro measurements of neurotransmitter release, immunohistochemistry and in situ hybridisation.
Czech DP*, Lee J*, Correia J, Loke H, Möller E, Harley VR (2014) Transient neuroprotection by SRY up-regulation in dopamine cells following injury in males. Endocrinology. Apr 7 [Epub] PMID: 24708242 (joint first author)
Lee, J. and Harley, V. (2012) The male fight-flight response: A result of SRY regulation of catecholamines? Bioessays. 34(6): 545-7
Czech, D.P., Lee, J., Sim, H., Parish, C.L., Vilain, E. and Harley, V.R. The human testis determining factor SRY localizes in the substantia nigra and regulates multiple components of dopamine synthesis and metabolism. (2012) Journal of Neurochemistry 122(2): 260-271
Lee, J., Parish, C.P., Tomas, D., Lawrence, A.J., HorneM.K. Chronic cocaine administration reduces striatal dopamine terminal density and striatal dopamine release which leads to drug-seeking behaviour. (2011) Neuroscience. 174c: 143-150
Lee, J., Zhu, W.M., Stanic, D., Finkelstein, D.I., Horne, M.H., Henderson, J., Lawrence, A.J., O’Connor, L., Tomas, D., Drago, J., and Horne, M.K. (2008) Sprouting of Dopamine Terminals and Altered Dopamine Release and Uptake in Parkinsonian Dyskinesia. Brain. 131 (pt6), 1574-87.