Professor Mark Hedger, Senior Principal Research Fellow

Professor Mark Hedger has worked in men’s reproductive health since completing his PhD at Monash University in 1984. Subsequently, he received an NIH Visiting Fellowship to work in the Gamete Biology Section, Laboratory of Reproductive and Developmental Toxicology at the National Institute of Environmental Health Sciences in North Carolina, USA. In 1987, he returned to Melbourne to take up an Australian Postdoctoral Research Fellowship with the Department of Anatomy at Monash University.

From 1991 until 1994 Professor Hedger was an inaugural NHMRC Wright Fellow at the Institute of Reproduction and Development (now the Hudson Institute of Medical Research). In 1993 he was appointed an Institute Senior Scientist/Laboratory Head, and in 1996, Deputy-Director of the Centre for Reproduction and Development. In 2001 he was awarded an NHMRC Senior Research Fellowship, a position he continued to hold until 2016. He received an Associate Professorial Fellowship through Monash University’s Department of Physiology in 2003, and is currently a Senior Principal Research Fellow at the Hudson Institute of Medical Research and Professor in the Department of Molecular and Translational Sciences at Monash University. He has published more than 150 scholarly reports and scientific papers, principally in the fields of male reproductive tract biology, activin biology and inflammatory disease in various tissues. His research was recognized as one of the NHMRC’s “10 of the Best” Research Projects in 2008. He also serves on the editorial board of the Andrologia, and is a Section Editor for the Journal of Reproductive Immunology.

Professor Hedger is a member of several Australian and international scientific societies and was President of the Society for Reproductive Biology (2009 -2012). He is a Fellow of the Society for Reproductive Biology and a Fellow of the Society for the Study of Reproduction (USA).

 

Selected publications

  • Nicolas N, Michel V, Bhushan S, Wahle E, Hayward S, Ludlow H, de Kretser DM, Loveland KL, Schuppe HC, Meinhardt A, Hedger MP, Fijak M (2017) Testicular activin and follistatin levels are elevated during the course of experimental autoimmune epididymo-orchitis in mice. Scientific Reports 7: 42391.

  • Michel V, Duan Y, Stoschek E, Bhushan S, Middendorff R, Young JM, Loveland KA, de Kretser DM, Hedger MP, Meinhardt A (2016) Uropathogenic Escherichia coli cause fibrotic remodelling of the epididymis. Journal of Pathology 240: 15-24.

  • Michel V, Pilatz A, Hedger MP, Meinhardt A (2015)  Epididymitis: revelations at the convergence of clinical and basic sciences. Asian Journal of Andrology 17: 756-763. (Review)

  • Holdsworth-Carson SJ, Craythorn RG, Winnall WR, Dhaliwal K, Genovese R, Nowell CJ, Rogers PAW, de Kretser DM, Hedger M, Girling JE (2015)  Follistatin is essential for the normal postnatal development and function of mouse oviduct and uterus. Reproduction, Fertility and Development 27: 985-999.

  • de Kretser DM, Bensley JG, Pettilä V, Linko R, Hedger MP, Hayward S, Allan C, McLachlan RI, Ludlow H, Phillips DJ (2013)  Serum activin A and B levels predict outcomes in patients with acute respiratory failure: a prospective cohort study. Critical Care 17: R263.

  • Hedger MP, de Kretser DM (2013)  The activins and their binding protein, follistatin – diagnostic and therapeutic targets in inflammatory disease and fibrosis. Cytokine and Growth Factor Reviews 24: 285-295. (Review)

  • Wu H, Chen Y, Winnall WR, Phillips DJ, Hedger MP (2012)  Acute regulation of activin A and its binding protein, follistatin, in serum and tissues following lipopolysaccharide treatment of adult mice. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 303: R665-675.

  • Winnall WR, Wu H, Sarraj M, Rogers PAW, de Kretser DM, Girling JE, Hedger MP (2013)  Expression patterns of activin, inhibin and follistatin variants in the adult male mouse reproductive tract suggest important roles in the epididymis and vas deferens. Reproduction, Fertility and Development 25:570-580.

  • Hedger MP (2011)  Immunophysiology and pathology of inflammation in the testis and epididymis. Journal of Andrology 32: 625-640. (Review)

  • Winnall WR, Muir JA, Hedger MP (2011)  Rat resident testicular macrophages have an alternatively-activated phenotype and constitutively produce interleukin-10 in vitro. Journal of Leukocyte Biology 90: 133-143.