Dr Nataliya Zhukova, My Room Clinical Research Fellow

Dr Nataliya Zhukova is an early career researcher in the Developmental and Cancer Biology lab, and a  paediatric molecular oncology scientist for the Hudson Monash Paediatric Precision Medicine Program at Hudson Institute.  Dr Zhukova holds an Adjunct Research Fellow appointment in the Department of Paediatrics, School of Clinical Sciences at Monash Health, Faculty of Medicine Nursing and Health Sciences at Monash University, and is also a Paediatric Oncology Fellow at the Children’s Cancer Centre of the Monash Children’s Hospital. She is the recipient of a prestigious “My Room” Clinical Research Fellowship, awarded by the Children’s Cancer Foundation.

Dr Zhukova has a strong interest in paediatric brain cancers.  Her interests focus on combining biological, clinical, and translational knowledge at the junction of neurooncology, molecular oncology and cancer genetics to study molecular markers to understand tumourigenesis, improve risk-stratification and develop novel therapies to maximise survival and decrease short- and long-term side-effects in this population.

Dr Zhukova completed her medical training at the Kharkiv National Medical University, Ukraine (2000). She earned her BSc (Hons) in Molecular Biology and Genetics (2008) followed by her Master’s Degree (2012) in Molecular Oncology and Cancer Genetics from the University of Toronto, Canada. During her Master’s, under the supervision of Drs Uri Tabori and David Malkin, Dr Zhukova conducted a multicentre international study to establish a novel TP53-mutation-enriched subgroup of Sonic-Hedgehog medulloblastoma with poor prognosis, which has changed clinical practice internationally.

In late 2012, Dr Zhukova was granted a Clinician Scholar Award to continue her clinical research training at the Hospital for Sick Children in Toronto with Dr Tabori, in the Genetics & Genome Biology Program of the Arthur and Sonia Labatt Brain Tumour Research Centre. There, during her Postdoctoral Fellowship, she focused on defining molecular subgroups of paediatric low-grade glioma and its implications on disease progression, tumour transformation, and therapeutic strategies. Her contribution to paediatric brain cancer research has been recognised by the Society of International Pediatric Oncology (SIOP),  Young Investigator Award. Later, she extended her expertise into hypermutated cancers and biology of the biallelic mismatch repair deficiency (BMMRD) cancer predisposition syndrome though extensive clinical and research work with the BMMRD Consortium, led by Drs Uri Tabori and Eric Bouffet from the Hospital for Sick Children.

Dr Zhukova came to Australia in 2017 to expand her clinical expertise in paediatric malignancies and was a Clinical Fellow at the Royal Children’s Hospital and the Children’s Cancer Centre at Monash Children’s Hospital for two years prior being recruited by Hudson Institute in April 2019.

Dr Zhukova has devoted her translational research career to improving outcomes for children with high risk cancer, with her scientific work resulting in many peer-reviewed high impact publications and contributing to a number of clinical trials, including targeted therapy studies.

Selected publications

  • Guerreiro Stucklin AS, Ryall S, Fukuoka K, Zapotocky M, Lassaletta A, Bridge T, Kim B, Li C, Arnoldo A, Kowalski P, Zhong Y, Johnson M, Li CI, Ramani A, Siddaway R, Dunham C, Cheng S, Boué DR, Finlay JL, Coven SL, De Prada I, Perez-Somarriba M, Faria C, Grotzer MA,  Rushing E, Sumerauer D, Zamecnik J, Krskova L, Ariza MG, Cruz O, La Madrid AM, Solano P, Terashima K, Nakano Y, Ichimura K, Gil-da-Costa MJ, Silva R, Johnston DL, Michaud J,  Wilson B, Van Landeghem F, Oviedo A, McNeely D, Crooks B,  Fried I, Zhukova N, Hansford J, Nageswararao A, Shago M, Irwin MS, Bartels U, Ramaswamy V, Huang A, Bouffet E, Taylor M, Tabori U, Hawkins C (2019) Alterations in ALK/ROS1/NTRK/MET drive a group of infantile hemispheric gliomas. Nat Commun 10:4343.

  • Shuen AY, Lanni S, Panigrahi GB, Edwards M, Yu L, Campbell BB, Mandel A, Zhang C, Zhukova N, Alharbi M, Bernstein M, Bowers DC, Carroll S, Cole KA, Constantini S, Crooks B, Dvir R, Farah R, Hijiya N, George B, Laetsch TW, Larouche V, Lindhorst S, Luiten RC, Magimairajan V, Mason G, Mason W, Mordechai O, Mushtaq N, Nicholas G, Oren M, Palma L, Pedroza LA, Ramdas J, Samuel D, Wolfe Schneider K, Seeley A, Semotiuk K, Shamvil A, Sumerauer D, Toledano H, Tomboc P, Wierman M, Van Damme A, Lee YY, Zapotocky M, Bouffet E, Durno C, Aronson M, Gallinger S, Foulkes WD, Malkin D, Tabori U, Pearson CE (2019) Functional repair assay for the diagnosis of constitutional mismatch repair deficiency from non-neoplastic tissue. J Clin Oncol 37:461-470.

  • Zhukova N, Rajagopal R, Lam A, Coleman L, Shipman P, Walwyn T, Williams M, Sullivan M, Campbell M, Bhatia K, Gottardo NG, Hansford JR (2019) Use of Bevacizumab as a single agent or in adjunct with traditional chemotherapy regimens in children with unresectable or progressive low-grade glioma. Cancer Med 8:40-50.

  • Bouffet E, Larouche V, Campbell BB, Merico D, de Borja R, Aronson M, Durno C, Krueger J, Cabric V, Ramaswamy V, Zhukova N, Mason G, Farah R, Afzal S, Yalon M, Rechavi G, Magimairajan V, Walsh MF, Constantini S, Dvir R, Elhasid R, Reddy A, Osborn M, Sullivan M, Hansford J, Dodgshun A, Klauber-Demore N, Peterson L, Patel S, Lindhorst S, Atkinson J, Cohen Z, Laframboise R, Dirks P, Taylor M, Malkin D, Albrecht S, Dudley RW, Jabado N, Hawkins CE, Shlien A, Tabori U (2016) Immune Checkpoint Inhibition for Hypermutant Glioblastoma Multiforme Resulting From Germline Biallelic Mismatch Repair Deficiency. J Clin Oncol 4:2206-2211.

  • Mistry M, Zhukova N, Merico D, Rakopoulos P, Krishnatry R, Shago M, Stavropoulos J, Alon N, Pole JD, Ray PN, Navickiene V, Mangerel J, Remke M, Buczkowicz P, Ramaswamy V, Guerreiro Stucklin A, Li M, Young EJ, Zhang C, Castelo-Branco P, Bakry D, Laughlin S, Shlien A, Chan J, Ligon KL, Rutka JT, Dirks PB, Taylor MD, Greenberg M, Malkin D, Huang A, Bouffet E, Hawkins CE, Tabori U (2015)  BRAF mutation and CDKN2A deletion define a clinically distinct subgroup of childhood secondary high-grade glioma. J Clin Oncol 33:1015-1022.

  • Zhukova N, Ramaswamy V, Remke M, Martin DC, Castelo-Branco P, Zhang CH, Fraser M, Tse K, Poon R, Shih DJ, Baskin B, Ray PN, Bouffet E, Dirks P, von Bueren AO, Pfaff E, Korshunov A, Jones DT, Northcott PA, Kool M, Pugh TJ, Pomeroy SL, Cho YJ, Pietsch T, Gessi M, Rutkowski S, Bognár L, Cho BK, Eberhart CG, Conter CF, Fouladi M, French PJ, Grajkowska WA, Gupta N, Hauser P, Jabado N, Vasiljevic A, Jung S, Kim SK, Klekner A, Kumabe T, Lach B, Leonard JR, Liau LM, Massimi L, Pollack IF, Ra YS, Rubin JB, Van Meir EG, Wang KC, Weiss WA, Zitterbart K, Bristow RG, Alman B, Hawkins CE, Malkin D, Clifford SC, Pfister SM, Taylor MD, Tabori U (2014) WNT activation by lithium abrogates mutant TP53 radiation resistance in medulloblastoma. Acta Neuropathol Commun 2:174.

  • Zhukova N, Ramaswamy V, Remke M, Pfaff E, Shih DJ, Martin DC, Castelo-Branco P, Baskin B, Ray PN, Bouffet E, von Bueren AO, Jones DT, Northcott PA, Kool M, Sturm D, Pugh TJ, Pomeroy SL, Cho YJ, Pietsch T, Gessi M, Rutkowski S, Bognar L, Klekner A, Cho BK, Kim SK, Wang KC, Eberhart CG, Fevre-Montange M, Fouladi M, French PJ, Kros M, Grajkowska WA, Gupta N, Weiss WA, Hauser P, Jabado N, Jouvet A, Jung S, Kumabe T, Lach B, Leonard JR, Rubin JB, Liau LM, Massimi L, Pollack IF, Shin Ra Y, Van Meir EG, Zitterbart K, Schüller U, Hill RM, Lindsey JC, Schwalbe EC, Bailey S, Ellison DW, Hawkins C, Malkin D, Clifford SC, Korshunov A, Pfister S, Taylor MD, Tabori U (2013) Subgroup-specific Prognostic Implications of TP53 Mutation in Medulloblastoma. J Clin Oncol 31:2927-2935.

  • Complete bibliography is available here: https://research.monash.edu/en/persons/nataliya-zhukova