Dr Peter Stanton’s research interests lie in the hormonal regulation of cell junctions in the testis, as part of the search for testicular targets of male hormonal contraception. His work has focussed on cell junctions between Sertoli and germ cells, and more recently between Sertoli cells, with particular reference to their regulation by gonadotrophins.
With specific skills in biomolecular separation and characterisation, and has applied these skills to the assessment of serum and testicular steroids and hormones in rats and men during male hormonal contraception.
More recently, Dr Stanton has worked closely with colleagues to oversee the establishment of a core-facility proteomics laboratory at the Hudson Institute of Medical Research. Dr Stanton is now involved in a program of proteomic studies aimed at identifying new contraceptive targets and diagnostic markers of various conditions including male and female infertility. He is also involved with Hudson Institute colleagues in inhibin research.
O’Donnell L, Pratis K, Wagenfeld A, Gottwald U, Mueller J, Leder G, McLachlan RI, Stanton PG (2009) Transcriptional profiling of the hormone-responsive stages of spermatogenesis reveals cell-, stage- and hormone-specific events. Endocrinology 150:5074–5084.
McCabe MJ, Tarulli GA, Meachem SJ, Robertson DM, Smooker PM, Stanton PG (2010) Gonadotropins regulate rat testicular tight junctions in vivo. Endocrinology 151:2911-2922.
Nicholls PK, Harrison CA, Walton KL, McLachlan RI, O’Donnell L, Stanton PG (2011) Hormonal Regulation of Sertoli Cell microRNAs at Spermiation. Endocrinology 152:1670-1683.
Stanton PG, Sluka P, Foo CF, Stephens AN, Smith AI, McLachlan RI, O’Donnell L (2012) Proteomic changes in rat spermatogenesis in response to in vivo androgen manipulation; impact on meiotic cells. PLoS One 7:e41718.
McCabe MJ, Allan CM, Foo CF, Nicholls PK, McTavish KJ, Stanton PG (2012) Androgen initiates Sertoli cell tight junction formation in the hypogonadal (hpg) mouse. Biol Reprod 87(2): 38.
Nicholls PK, Stanton PG, Chen JL, Haverfield JT, Qian, H, Walton KL, Gregorevic P, Harrison CA (2012) Activin signalling regulates Sertoli cell differentiation and function. Endocrinology 153(12):6065-6077.
Nicholls PK, Harrison CA, Rainczuk KE, Vogl AW, Stanton PG(2013) Retinoic acid promotes Sertoli cell differentiation and antagonises activin induced proliferation. Mol Cell Endocrinol 377:33–43.
Simpson CM, Robertson DM, Al-Musawi SL, Heath DA, McNatty KP, Ritter LJ, Mottershead DG, Gilchrist RB, Harrison CA, Stanton PG (2014) Aberrant GDF9 expression and activation is associated with common human ovarian disorders. J Clin Endocrinol Metab 99:E615-24.
Haverfield JT, Meachem SJ, Nicholls PK, Rainczuk KE, Simpson ER, Stanton PG (2014) Differential permeability of the blood-testis barrier during re-initiation of spermatogenesis in adult male rats. Endocrinology 155:1131-44.
McCabe MJ, Tarulli GA, Laven-Law G, Matthieson KL, Meachem SJ, McLachlan RI, Dinger ME, Stanton PG (2016) Gonadotrophin suppression in men leads to a reduction in claudin-11 at the Sertoli cell tight junction. Human Reprod 31:875-886.
O’Donnell L, Stanton PG, de Kretser DM (2017) Endocrinology of the male reproductive system and spermatogenesis. In: De Groot LJ, Chrousos G, Dungan K, Feingold KR, Grossman A, Hershman JM, Koch C, Korbonits M, McLachlan R, New M, Purnell J, Rebar R, Singer F, Vinik A, editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000-2016 Dec 18. Review.