Pelvic organ prolapse (POP)

One single endometrial mesenchymal stem cell attaches and interacts with nanofibres at nanoscale

Feature image | One single endometrial mesenchymal stem
cell attaches to and interacts with nanofibres at nanoscale.

Pelvic organ prolapse (POP)

POP is a hidden condition. While the injury happens mostly during childbirth, the patient may not know about the damage until many years later, often during menopause.

There is no reliable cure for pelvic organ prolapse. Hudson Institute researchers are striving to discover an effective, safe treatment option for the many women who are suffering in silence.

What is pelvic organ prolapse?

Pelvic organ prolapse symptoms

Pelvic organ prolapse stages

Pelvic organ prolapse treatment

Our pelvic organ prolapse (POP) research

Hudson Institute researchers are committed to finding new treatments for those affected by pelvic organ prolapse.

In a world-first approach, Hudson Institute scientists are using adult stem cells (mesenchymal stem cells) from the lining of a woman’s own uterus engineered with biodegradable materials to develop safe, effective treatments for pelvic organ prolapse. They have dedicated more than ten years to find a safe and effective treatment option for POP and are pioneering world-first treatment approaches.

Initially the team worked with CSIRO to develop a new flexible non-degradable mesh to support the vagina and deliver endometrial mesenchymal stem cells.  This tissue engineering construct significantly improved the outcome in pre-clinical models. As a result of this work, the team is focusing on a new degradable biocompatible material that provides a good healing.

Feature video | Professor Caroline Gargett and Dr Shayanti Mukherjee appeared in a recent TV news report about their latest breakthrough research.

New pelvic organ prolapse treatment – nanostructured and 3D bioprinted cellular surgical constructs

Dr Shayanti Mukherjee from the Endometrial Stem Cell Biology Research Group at Hudson InstituteThis project is investigating a new pelvic organ prolapse treatment using regenerative medicine – a cell-based therapy delivered in degradable biomaterial constructs. The team are examining the effect of using these constructs as surgical implants.

Preparing endometrial mesenchymal stem cells for clinical treatment

Preventing pelvic organ prolapse by treating vaginal injury

Pelvic organ prolapse collaborators

Explore our pelvic organ prolapse labs

Support for people with pelvic organ prolapse

Our scientists cannot provide medical advice.
If you would like to find out more information about pelvic organ prolapse (POP), please visit

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