There is currently no effective treatment for ovarian cancer that achieves long-term patient survival. Dr Maree Bilandzic’s research program has a strong focus on addressing the unmet needs faced by women battling ovarian cancer: the lack of effective treatments and ways to monitor disease.
Dr Bilandzic is particularly focused on a specialised subset of ovarian cancer cells called “Leader Cells”. Leader cells are fundamental to metastasis, tumour progression and chemo resistance, yet not much is known about them in an ovarian cancer context.
Dr Bilandzic has been fortunate to receive support from philanthropic organisations such as the CASS Foundation, Fielding Foundation and the Ovarian Cancer Research Foundation. Her studies are facilitated by strong clinical collaborations within the Monash Health Translation Precinct.
Dr Bilandzic believes that understanding the molecules and pathways controlling critical stages of metastasis is essential to enable the development of treatments that specifically counter the dual problems associated with chemoresistance and tumour spread.
Moffitt LR, Bilandzic M, Wilson AL, Chen Y, Gorrell MD, Oehler MK, Plebanski M, Stephens AN (2020) Hypoxia Regulates DPP4 Expression, Proteolytic Inactivation, and Shedding from Ovarian Cancer Cells. Int J Mol Sci 21:8110.
Moffitt L, Karimnia N, Stephens A, Bilandzic M (2019) Therapeutic Targeting of Collective Invasion in Ovarian Cancer. Int J Mol Sci 20:1466.
Bilandzic M, Rainczuk A, Green E, Fairweather N, Jobling TW, Plebanski M, Stephens AN (2019) Keratin-14 (KRT14) Positive Leader Cells Mediate Mesothelial Clearance and Invasion by Ovarian Cancer Cells. Cancers (Basel) 2019 Aug 22;11:1228.
Wilson AL, Wilson KL, Bilandzic M, Moffitt LR, Makanji M, Gorrell MD, Oehler MK, Rainczuk A, Stephens AN, Plebanski M (2018) Non-Invasive Fluorescent Monitoring of Ovarian Cancer in an Immunocompetent Mouse Model. Cancers (Basel) 11:32.
Sandow JJ, Rainczuk A, Infusini G, Makanji M, Bilandzic M, Wilson AL, Fairweather N, Stanton PG, Garama D, Gough D, Jobling TW, Webb AI, Stephens AN (2018) Discovery and Validation of Novel Protein Biomarkers in Ovarian Cancer Patient Urine. Proteomics Clin Appl 12:e1700135.