Gastroenteritis is a common disease of the gut that can be highly infectious and make you feel sick very quickly. It is triggered when the digestive system becomes infected and inflamed, causing abdominal cramps, diarrhoea and vomiting with severity ranging from a mild tummy upset to severe and life-threatening dehydration.
Gastroenteritis is a major burden in developing countries and can be fatal for infants, older adults and people with compromised immune systems. Diarrhoeal disease is the second leading cause of death in children under five and kills around 525,000 children globally every year.
Causes of gastroenteritis
Types of gastroenteritis
Symptoms of gastroenteritis
Prevention of gastroenteritis
Our gastroenteritis research
As antimicrobial resistance becomes more widespread and current treatment measures become less effective, the development of new therapeutics and vaccines for gastroenteritis is more important than ever.
Despite medical advances, gastroenteritis still kills many children and elderly people each year, particularly in developing countries. Our researchers are working on better vaccines and therapeutics to prevent severe gastroenteritis and save lives. This includes research to harness the protective properties of the human microbiome.
Hudson Institute researchers are using specialist preclinical infection models and genetic screens to lay the groundwork for improved drug efficacy and to understand the infection mechanisms of a diverse range of bacteria and viruses that cause life threatening disease. This work has the potential to rapidly advance the treatment of gastroenteritis and the prevention of serious illness or death.
Understanding the infection biology of E. coli and Shigella
Molecular studies. Professor Elizabeth Hartland’s team studies the protein secretion systems of bacteria including E. coli and Shigella that enable them to cause gastrointestinal infections. These systems are used by the bacteria to inject proteins into human cells that can manipulate cell processes and promote bacterial growth. The aim of this work is to investigate how these injected proteins interfere with host cell function, inflammation and the innate immune response that is needed to fight infection.
Research and development for Salmonella infections
Understanding how diet influences gastrointestinal infection outcomes
Understanding the role of a toxin in Campylobacter gastroenteritis
Diarrhoea-causing bacteria adapted to spread in hospitals
Mapping an emerging global health threat
ARC Discovery Projects success
Hudson Institute Emerging Leaders announced
Two Hudson Institute researchers receive prestigious veski Fellowship Awards
NHMRC Fellowship success
Stunning NHMRC Grant success
Childhood gastro link to type 1 diabetes
Help give children a healthier future
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- Imperial College London
- Institut Pasteur
- Walter and Eliza Hall Institute
- Peter Doherty Institute for Infection and Immunity
- Melbourne University
- Monash BDI
- Griffith University
- Naval Medical Research Center
- Wellcome Sanger Institute
- London School of Hygiene and Tropical Medicine
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